Leishmania aethiopica Field Isolates Bearing an Endosymbiontic dsRNA Virus Induce Pro-inflammatory Cytokine Response

@inproceedings{Zangger2014LeishmaniaAF,
  title={Leishmania aethiopica Field Isolates Bearing an Endosymbiontic dsRNA Virus Induce Pro-inflammatory Cytokine Response},
  author={Haroun Zangger and Asrat Hailu and Chantal Desponds and L F Lye and Natalia S. Akopyants and Deborah E. Dobson and Catherine Ronet and Hashim Warsama Ghalib and Stephen M Beverley and Nicolas Fasel},
  booktitle={PLoS neglected tropical diseases},
  year={2014}
}
BACKGROUND Infection with Leishmania parasites causes mainly cutaneous lesions at the site of the sand fly bite. Inflammatory metastatic forms have been reported with Leishmania species such as L. braziliensis, guyanensis and aethiopica. Little is known about the factors underlying such exacerbated clinical presentations. Leishmania RNA virus (LRV) is mainly found within South American Leishmania braziliensis and guyanensis. In a mouse model of L. guyanensis infection, its presence is… CONTINUE READING
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