• Corpus ID: 86091509

Leishmania Vaccines Updates

  title={Leishmania Vaccines Updates},
  author={Maha M. A. Basyoni},

Visceral Leishmaniasis: Advancements in Vaccine Development via Classical and Molecular Approaches

A review of newer approaches being utilized for vaccine development against VL, wherein proteomics based knowledge combined with computational techniques (immunoinformatics) speed up the identification and detailed characterization of new antigens for potential vaccine candidates, may eventually help in the designing of polyvalent synthetic and recombinant chimeric vaccines.

An overview on Leishmania vaccines: A narrative review article

  • H. RezvanM. Moafi
  • Medicine, Biology
    Veterinary research forum : an international quarterly journal
  • 2015
Vaccines successes in animal studies and some clinical trials clearly justify more researches and investments illuminating opportunities in suitable vaccine designation for Leishmania vaccination.

Leishmaniasis: recombinant DNA vaccination and different approaches for vaccine development

This review focuses on single or multi-proteins, epitopes and DNA vaccines that are capable of creating less or more partial protection in humans and dogs and a few limited vaccine formulations are licensed in Brazil and Europe just for canines.



Christian de Duve

Pioneer in modern cell biology and Nobel Prize winner

Experimental models for leishmaniasis and for testing anti-leishmanial vaccines.

This review discusses the concept of animal models for leishmaniases and provides a critical evaluation of the most common experimental models and their respective advantages and disadvantages, with particular emphasis on the value of using mouse, hamster, cotton-rat, dog and primate models, especially in the context of testing potential anti-leishmanial vaccines.

In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies

Infection with the obligate intracellular protozoan Leishmania major (L.m.m.) appears to have evolved to both evade and exploit the innate host response to sand fly bite in order to establish and promote disease.

Second-generation vaccines against leishmaniasis.

Immunological Perspectives of Leishmaniasis

An updated overview of immunological response considered to be of importance in protection, susceptibility, disease progression and cure of leishmaniasis, with a special emphasis on human diseases is given.