Visceral Leishmaniasis: Advancements in Vaccine Development via Classical and Molecular Approaches
- MedicineFront. Immunol.
A review of newer approaches being utilized for vaccine development against VL, wherein proteomics based knowledge combined with computational techniques (immunoinformatics) speed up the identification and detailed characterization of new antigens for potential vaccine candidates, may eventually help in the designing of polyvalent synthetic and recombinant chimeric vaccines.
Immunogenicity and efficacy of recombinant 78 kDa antigen of Leishmania donovani formulated in various adjuvants against murine visceral leishmaniasis.
- BiologyAsian Pacific journal of tropical medicine
An overview on Leishmania vaccines: A narrative review article
- Medicine, BiologyVeterinary research forum : an international quarterly journal
Vaccines successes in animal studies and some clinical trials clearly justify more researches and investments illuminating opportunities in suitable vaccine designation for Leishmania vaccination.
Leishmaniasis: recombinant DNA vaccination and different approaches for vaccine development
This review focuses on single or multi-proteins, epitopes and DNA vaccines that are capable of creating less or more partial protection in humans and dogs and a few limited vaccine formulations are licensed in Brazil and Europe just for canines.
SHOWING 1-10 OF 62 REFERENCES
IL-4 Rapidly Produced by Vβ4 Vα8 CD4+ T Cells Instructs Th2 Development and Susceptibility to Leishmania major in BALB/c Mice
Leishmania infantum sterol 24-c-methyltransferase formulated with MPL-SE induces cross-protection against L. major infection.
- Biology, MedicineVaccine
Comparative real-time kinetic analysis of human complement killing of Leishmania infantum promastigotes derived from axenic culture or from Phlebotomus perniciosus.
- Biology, MedicineMicrobes and infection
Experimental models for leishmaniasis and for testing anti-leishmanial vaccines.
- BiologyAnnals of tropical medicine and parasitology
This review discusses the concept of animal models for leishmaniases and provides a critical evaluation of the most common experimental models and their respective advantages and disadvantages, with particular emphasis on the value of using mouse, hamster, cotton-rat, dog and primate models, especially in the context of testing potential anti-leishmanial vaccines.
In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies
Infection with the obligate intracellular protozoan Leishmania major (L.m.m.) appears to have evolved to both evade and exploit the innate host response to sand fly bite in order to establish and promote disease.
A randomised, double-blind, controlled trial of a killed L. major vaccine plus BCG against zoonotic cutaneous leishmaniasis in Iran.
- Medicine, BiologyVaccine
Immunological Perspectives of Leishmaniasis
- Biology, MedicineJournal of global infectious diseases
An updated overview of immunological response considered to be of importance in protection, susceptibility, disease progression and cure of leishmaniasis, with a special emphasis on human diseases is given.