Leishmania LPG3 encodes a GRP94 homolog required for phosphoglycan synthesis implicated in parasite virulence but not viability.

@article{Descoteaux2002LeishmaniaLE,
  title={Leishmania LPG3 encodes a GRP94 homolog required for phosphoglycan synthesis implicated in parasite virulence but not viability.},
  author={Albert Descoteaux and Herbert A. Avila and Kai Zhang and Salvatore Joseph Turco and Stephen M Beverley},
  journal={The EMBO journal},
  year={2002},
  volume={21 17},
  pages={4458-69}
}
Leishmania promastigotes express an abundant cell surface glycoconjugate, lipophosphoglycan (LPG). LPG contains a polymer of the disaccharide-phosphate repeat unit Galbeta1,4Manalpha1-PO4, shared by other developmentally regulated molecules implicated in parasite virulence. Functional complementation of a Leishmania donovani LPG-defective mutant (OB1) accumulating a truncated LPG containing only the Manalpha1-PO4 residue of the first repeat unit identified LPG3, the Leishmania homolog of the… CONTINUE READING
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Identi®cation of genes by functional complemenation in the protozoan parasite Leishmania

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