Leiomyosarcoma with alternative lengthening of telomeres is associated with aggressive histologic features, loss of ATRX expression, and poor clinical outcome.

@article{Liau2015LeiomyosarcomaWA,
  title={Leiomyosarcoma with alternative lengthening of telomeres is associated with aggressive histologic features, loss of ATRX expression, and poor clinical outcome.},
  author={Jau-Yu Liau and J H Tsai and Yung-Ming Jeng and Jen-Chieh Lee and Hung-Han Hsu and C. Yang},
  journal={The American journal of surgical pathology},
  year={2015},
  volume={39 2},
  pages={236-44}
}
Leiomyosarcoma is an aggressive soft tissue sarcoma with poor patient survival. Recently, it was shown that 53% to 62% of leiomyosarcomas use the alternative lengthening of telomeres (ALT) as their telomere maintenance mechanism. The molecular basis of this mechanism has not been elucidated. Studies of pancreatic neuroendocrine tumor have suggested that the inactivation of either α-thalassemia/mental retardation syndrome X-linked (ATRX) or death domain-associated (DAXX) protein is associated… CONTINUE READING