Leiomyoma simultaneously impair endometrial BMP-2-mediated decidualization and anticoagulant expression through secretion of TGF-β3.

@article{Sinclair2011LeiomyomaSI,
  title={Leiomyoma simultaneously impair endometrial BMP-2-mediated decidualization and anticoagulant expression through secretion of TGF-β3.},
  author={Donna C Sinclair and Alex Mastroyannis and Hugh S. Taylor},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2011},
  volume={96 2},
  pages={412-21}
}
CONTEXT Uterine leiomyomas occur in 30-70% of reproductive-age women. Leiomyoma reduce implantation, increase miscarriage risk, and increase menstrual bleeding. We hypothesized that endometrial defects induced by leiomyoma result in menorrhagia and reproductive dysfunction. OBJECTIVES We evaluated the effect of leiomyoma on endometrial gene expression essential for implantation and hemostasis both in vivo and in primary endometrial stromal cells (ESC). DESIGN AND SETTING We conducted a case… CONTINUE READING

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