Leiomodin is an actin filament nucleator in muscle cells.

  title={Leiomodin is an actin filament nucleator in muscle cells.},
  author={David Chereau and Malgorzata Boczkowska and Aneta Skwarek-Maruszewska and Ikuko Fujiwara and David B. Hayes and Grzegorz Rebowski and Pekka Lappalainen and Thomas D. Pollard and Roberto Dom{\'i}nguez},
  volume={320 5873},
Initiation of actin polymerization in cells requires nucleation factors. Here we describe an actin-binding protein, leiomodin, that acted as a strong filament nucleator in muscle cells. Leiomodin shared two actin-binding sites with the filament pointed end-capping protein tropomodulin: a flexible N-terminal region and a leucine-rich repeat domain. Leiomodin also contained a C-terminal extension of 150 residues. The smallest fragment with strong nucleation activity included the leucine-rich… CONTINUE READING
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