Leiomodin-3-deficient mice display nemaline myopathy with fast-myofiber atrophy

@inproceedings{Tian2015Leiomodin3deficientMD,
  title={Leiomodin-3-deficient mice display nemaline myopathy with fast-myofiber atrophy},
  author={Lei Tian and Sheng Ding and Yun Qi You and Tong-ruei Li and Yan Liu and Xiaohui Wu and Ling Min Sun and Tian Xu},
  booktitle={Disease models & mechanisms},
  year={2015}
}
Nemaline myopathy (NM) is one of the most common forms of congenital myopathy, and affects either fast myofibers, slow myofibers, or both. However, an animal model for congenital myopathy with fast-myofiber-specific atrophy is not available. Furthermore, mutations in the leiomodin-3 (LMOD3) gene have recently been identified in a group of individuals with NM. However, it is not clear how loss of LMOD3 leads to NM. Here, we report a mouse mutant in which the piggyBac (PB) transposon is inserted… CONTINUE READING
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