Leiomodin-2 is an antagonist of tropomodulin-1 at the pointed end of the thin filaments in cardiac muscle.

@article{Tsukada2010Leiomodin2IA,
  title={Leiomodin-2 is an antagonist of tropomodulin-1 at the pointed end of the thin filaments in cardiac muscle.},
  author={Takehiro Tsukada and Christopher T. Pappas and Natalia A. Moroz and Parker B. Antin and Alla S. Kostyukova and Carol C. Gregorio},
  journal={Journal of cell science},
  year={2010},
  volume={123 Pt 18},
  pages={3136-45}
}
Regulation of actin filament assembly is essential for efficient contractile activity in striated muscle. Leiomodin is an actin-binding protein and homolog of the pointed-end capping protein, tropomodulin. These proteins are structurally similar, sharing a common domain organization that includes two actin-binding sites. Leiomodin also contains a unique C-terminal extension that has a third actin-binding WH2 domain. Recently, the striated-muscle-specific isoform of leiomodin (Lmod2) was… CONTINUE READING

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