Leigh disease (subacute necrotizing encephalomyelopathy): MR documentation of the evolution of an acute attack.

@article{Heckmann1993LeighD,
  title={Leigh disease (subacute necrotizing encephalomyelopathy): MR documentation of the evolution of an acute attack.},
  author={Jeannine M Heckmann and Richard Eastman and Leonard Handler and Michael Scott Wright and Philip Owen},
  journal={AJNR. American journal of neuroradiology},
  year={1993},
  volume={14 5},
  pages={1157-9}
}
The radiologic evolution of Leigh disease is documented with sequential brain MR in the acute phase of the illness, at 3 weeks, and at 3 months. High-signal-intensity lesions seen on T2-weighted images in the first week resolved by 3 months, whereas new lesions appear during the chronic stage. Putamenal involvement is not a pathognomonic radiologic finding. Brain stem tegmentum, particularly the mesencephalon, is characteristically involved on MR in the early and late phases of the illness. 

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Magnetic resonance imaging in a case of autopsy-proven adult subacute necrotizing encephalomyelopathy (Leigh 's disease)

  • JT Kissel, S Kolkin, D Chakares, C Boesel, K. Weiss
  • Arch Neural
  • 1987
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