Legionella pneumophila type II secretion dampens the cytokine response of infected macrophages and epithelia.

@article{McCoySimandle2011LegionellaPT,
  title={Legionella pneumophila type II secretion dampens the cytokine response of infected macrophages and epithelia.},
  author={Kessler McCoy-Simandle and Catherine R. Stewart and Jenny Dao and Sruti Debroy and Ombeline Rossier and P J Bryce and Nicholas P. Cianciotto},
  journal={Infection and immunity},
  year={2011},
  volume={79 5},
  pages={1984-97}
}
The type II secretion (T2S) system of Legionella pneumophila is required for the ability of the bacterium to grow within the lungs of A/J mice. By utilizing mutants lacking T2S (lsp), we now document that T2S promotes the intracellular infection of both multiple types of macrophages and lung epithelia. Following infection of macrophages, lsp mutants (but… CONTINUE READING