Legionella pneumophila subversion of host vesicular transport by SidC effector proteins.

Abstract

Tethering proteins play a key role in vesicular transport, ensuring that cargo arrives at a specific destination. The bacterial effector protein SidC and its paralog SdcA have been described as tethering factors encoded by the intracellular pathogen Legionella pneumophila. Here, we demonstrate that SidC proteins are important for early events unique to maturation of vacuoles containing Legionella and discover monoubiquitination of Rab1 as a new SidC-dependent activity. The crystal structure of the SidC N-terminus revealed a novel fold that is important for function and could be involved in Legionella adaptations to evolutionarily divergent host cells it encounters in natural environments.

DOI: 10.1111/tra.12158
02040602014201520162017
Citations per Year

60 Citations

Semantic Scholar estimates that this publication has 60 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Horenkamp2014LegionellaPS, title={Legionella pneumophila subversion of host vesicular transport by SidC effector proteins.}, author={Florian A. Horenkamp and Shaeri Mukherjee and Eric Alix and Curtis M. Schauder and Andree M Hubber and Craig R. Roy and Karin M Reinisch}, journal={Traffic}, year={2014}, volume={15 5}, pages={488-99} }