Legionella pneumophila adaptation to intracellular life and the host response: Clues from genomics and transcriptomics

@article{Jules2007LegionellaPA,
  title={Legionella pneumophila adaptation to intracellular life and the host response: Clues from genomics and transcriptomics},
  author={Matthieu Jules and Carmen Buchrieser},
  journal={FEBS Letters},
  year={2007},
  volume={581}
}
Legionella Pneumophila Transcriptome during Intracellular Multiplication in Human Macrophages
TLDR
This study provides a comprehensive view of how L. pneumophila responds to the human macrophage intracellular environment and predicts previously unrecognized Icm/Dot effector genes based on their expression pattern and confirmed translocation for three candidates.
Identification and characterisation of novel Legionella pneumophila virulence genes
TLDR
34 mutants of L. pneumophila transposon mutants for attenuated intracellular replication within the amoebae Acanthamoeba castellanii were constructed and 34 insertions into seven novel genes were discovered, including lpw27511 and sdeC, which encodes a Dot/Icm translocated effector and were investigated further.
Legionella pneumophila: population genetics, phylogeny and genomics.
Inflammasome Recognition and Regulation of the Legionella Flagellum.
TLDR
The production of L. pneumophila flagellin and pathogen-host interactions are controlled by a complex stationary phase regulatory network, detecting nutrient availability as well as the Legionella quorum sensing (Lqs) signaling compound LAI-1 (3-hydroxypentadecane-4-one).
The origins of eukaryotic-like proteins in Legionella pneumophila.
Sequencing Illustrates the Transcriptional Response of Legionella pneumophila during Infection and Identifies Seventy Novel Small Non-Coding RNAs
TLDR
Analysis of strand specific sequencing of the transcriptional response of L. pneumophila during exponential and post-exponential broth growth and during the replicative and transmissive phase of infection inside A. castellanii shows that the newly discovered 6S RNA as well as a number of other non-coding RNAs show evidence for antisense transcription.
Effector translocation by the Legionella Dot/Icm type IV secretion system.
TLDR
Recent advancements in the understanding of the factors that determine the protein translocation activity of the Dot/Icm transporter are summarized.
Phagocytosis and host-pathogen interactions in Dictyostelium with a look at macrophages.
Intracellular Growth and Morphological Characteristics of Legionella pneumophila during Invasion and Proliferation in Different Cells.
TLDR
The results showed that the two newly tested cell lines are able to support the intracellular proliferation of L. pneumophila, and there were some morphological variations during the invasion and intrACEllular replication of L.'s pneumophilia within different hosts.
Effector Glycosyltransferases in Legionella
TLDR
Legionella genomes disclose several genes, coding for effector proteins likely to possess glycosyltransferase activities, including SetA (subversion of eukaryotic vesicle trafficking A), which influences vesicular trafficking in the yeast model system and displays tropism for late endosomal/lysosomal compartments of mammalian cells.
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