Legionella pneumophila Is Internalized by a Macropinocytotic Uptake Pathway Controlled by the Dot/Icm System and the Mouse Lgn1 Locus✪

Abstract

The products of the Legionella pneumophila dot/icm genes enable the bacterium to replicate within a macrophage vacuole. This study demonstrates that the Dot/Icm machinery promotes macropinocytotic uptake of L. pneumophila into mouse macrophages. In mouse strains harboring a permissive Lgn1 allele, L. pneumophila promoted formation of vacuoles that were… (More)

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@article{Watarai2001LegionellaPI, title={Legionella pneumophila Is Internalized by a Macropinocytotic Uptake Pathway Controlled by the Dot/Icm System and the Mouse Lgn1 Locus✪}, author={Masahisa Watarai and Isabelle Derr{\'e} and James Kirby and Joseph D. Growney and William F. Dietrich and Ralph R. Isberg}, journal={The Journal of Experimental Medicine}, year={2001}, volume={194}, pages={1081 - 1096} }