Legg‐Calvé‐Perthes Disease

@article{Kim2010LeggCalvPerthesD,
  title={Legg‐Calv{\'e}‐Perthes Disease},
  author={Harry K.W. Kim},
  journal={American Academy of Orthopaedic Surgeon},
  year={2010},
  volume={18},
  pages={676–686}
}
  • H. Kim
  • Published 1 November 2010
  • Medicine
  • American Academy of Orthopaedic Surgeon
&NA; Legg‐Calvé‐Perthes disease is an idiopathic hip disorder that produces ischemic necrosis of the growing femoral head. Permanent femoral head deformity is the most significant sequela. Experimental studies indicate that the pathologic repair process, which is marked by an imbalance of bone resorption and formation, contributes to the pathogenesis of femoral head deformity. Important prognostic factors include degree of deformity, age at disease onset, extent of head involvement, head‐at… 

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Legg‐Calvé‐Perthes Disease Produces Chronic Hip Synovitis and Elevation of Interleukin‐6 in the Synovial Fluid

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    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2015
In the active stage of LCPD, chronic hip synovitis and significant elevation of IL‐6 are produced in the synovial fluid, and IL‐1β and TNF‐α levels were not elevated.
...

References

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The femoral head was more likely to undergo progressive flattening in older patients, in Those with more severe lateral pillar involvement, and in those with prolonged reossification.

Treatment of severe late-onset Perthes’ disease with soft tissue release and articulated hip distraction: revisited at skeletal maturity

A combination of soft tissue release and joint distraction with a hinged mono-lateral external fixator for these patients with late-onset Perthes’ disease is used as a salvage procedure.

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Results indicate that the deterioration of the mechanical properties of the epiphyseal bone and cartilage likely plays a significant role in the pathogenesis of the femoral head deformity in LCPD.
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