Leg ulcers in sickle cell disease.

  title={Leg ulcers in sickle cell disease.},
  author={Caterina P Minniti and James Eckman and Paola Sebastiani and Martin H Steinberg and Samir K Ballas},
  journal={Hematology/oncology clinics of North America},
  volume={10 6},
Sickle cell disease is a single amino acid molecular disorder of hemoglobin leading to its pathological polymerization, red cell rigidity that causes poor microvascular blood flow, with consequent tissue ischemia and infarction. The manifestations of this disease are protean.Among them, leg ulcers represent a particularly disabling and chronic complication, often associated with a more severe clinical course.Despite the fact that this complication has been recognized since the early times of… CONTINUE READING
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