Left ventricular unloading alters receptor tyrosine kinase expression in the failing human heart.

@article{Uray2002LeftVU,
  title={Left ventricular unloading alters receptor tyrosine kinase expression in the failing human heart.},
  author={Iv{\'a}n P. Uray and John H. Connelly and Vilmos A. Thomazy and Gregory L. Shipley and William K. Vaughn and O. Howard Frazier and Heinrich Taegtmeyer and Peter J.A. Davies},
  journal={The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation},
  year={2002},
  volume={21 7},
  pages={771-82}
}
BACKGROUND Experimental and clinical data suggest that the loss of membrane receptor tyrosine kinase (RTK) activity in cardiac myocytes results in increased frequency of apoptotic cell death and progression of heart failure. The goal of our study was to examine the expression characteristics of RTKs in ventricular myocardium obtained from patients before and after mechanical unloading. METHODS We extracted RNA from paired formalin-fixed, paraffin-embedded left ventricular tissue blocks… CONTINUE READING

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