Left ventricular targeting of reporter gene expression in vivo by human BNP promoter in an adenoviral vector.

@article{Lapointe2002LeftVT,
  title={Left ventricular targeting of reporter gene expression in vivo by human BNP promoter in an adenoviral vector.},
  author={Margot C. Lapointe and Xiao-Ping Yang and Oscar A. Carretero and Quan He},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2002},
  volume={283 4},
  pages={H1439-45}
}
To selectively introduce genes into the mouse myocardium, we used a recombinant adenovirus encoding a transgene composed of a cardiac-specific promoter [the proximal human brain natriuretic peptide (hBNP) promoter] coupled to a luciferase reporter gene (Ad.hBNPLuc). Activity in vitro and in vivo was compared with Ad.CMVLuc, which contained the… CONTINUE READING