Left ventricular pressure-volume relationship in conscious mice.

  title={Left ventricular pressure-volume relationship in conscious mice.},
  author={Shuji Joho and Shinji Ishizaka and Richard E. Sievers and E. Terry Foster and Paul C. Simpson and William M. Grossman},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={292 1},
With the availability of transgenic models, the mouse has become an increasingly important subject for genetic-hemodynamic studies. Recently, we developed a technique to measure left ventricular (LV) pressure in conscious mice with an implanted LV polyethylene tube. We extended our new method by evaluating the LV pressure-volume relationship and examined the feasibility of this method in this study. We studied 17 male mice (age, 11-20 wk) with a conductance catheter inserted into the LV through… CONTINUE READING