Left ventricular mass and fluid compartmentalization in Wistar-Kyoto and spontaneously hypertensive rats fed high- or low-sodium diet.

Our purpose was to test the hypothesis that a high sodium intake promotes fluid volume expansion, and hence weight gain, in the left ventricle. Between 6 and 30 weeks of age, Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) were fed low-, control- or high-sodium chow. After treatment, known quantities of 22NaCl and Na2(35)SO4 were injected… CONTINUE READING