Left ventricular hypertrophy and renin-angiotensin system blockade.

  title={Left ventricular hypertrophy and renin-angiotensin system blockade.},
  author={Brett R. Cowan and Alistair A. Young},
  journal={Current hypertension reports},
  volume={11 3},
The renin-angiotensin system (RAS), an important control system for blood pressure and intravascular volume, also causes left ventricular hypertrophy (LVH) and fibrosis. The main causal mechanism is the increase in blood pressure, which leads to increased left ventricular wall stress; however, aldosterone release from the adrenals and (more controversially) the direct action of angiotensin II on the cardiomyocytes also play a role. Large clinical trials evaluating the blockade of the RAS with… CONTINUE READING


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