Left ventricular diastolic dysfunction and myocardial stiffness in diabetic mice is attenuated by inhibition of dipeptidyl peptidase 4.

@article{Hamdani2014LeftVD,
  title={Left ventricular diastolic dysfunction and myocardial stiffness in diabetic mice is attenuated by inhibition of dipeptidyl peptidase 4.},
  author={Nazha Hamdani and Anne-Sophie Hervent and Leni Vandekerckhove and Veerle Matheeussen and Marc J. Demolder and Lesley Baerts and Ingrid de Meester and Wolfgang A Linke and Walter Paulus and Gilles W. De Keulenaer},
  journal={Cardiovascular research},
  year={2014},
  volume={104 3},
  pages={423-31}
}
AIMS Obesity and Type 2 diabetes mellitus (DM) induce left ventricular (LV) diastolic dysfunction, which contributes to an increasing prevalence of heart failure with a preserved LV ejection fraction. We investigated the effects of sitagliptin (SITA), an inhibitor of dipeptidylpeptidase-4 (DPP-4) and anti-diabetic drug, on LV structure and function of obese… CONTINUE READING