Left-right patterning: conserved and divergent mechanisms.

@article{Nakamura2012LeftrightPC,
  title={Left-right patterning: conserved and divergent mechanisms.},
  author={Tetsuya Nakamura and Hiroshi Hamada},
  journal={Development},
  year={2012},
  volume={139 18},
  pages={3257-62}
}
The left-right (LR) asymmetry of visceral organs is fundamental to their function and position within the body. Over the past decade or so, the molecular mechanisms underlying the establishment of such LR asymmetry have been revealed in many vertebrate and invertebrate model organisms. These studies have identified a gene network that contributes to this process and is highly conserved from sea urchin to mouse. By contrast, some specific steps of the process, such as the symmetry-breaking event… CONTINUE READING
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