Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors.

@article{Shinohara2008LeftrightAO,
  title={Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors.},
  author={Yoshiaki Shinohara and Hajime Hirase and Masahiko Watanabe and Makoto Itakura and Masami Takahashi and Ryuichi Shigemoto},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 49},
  pages={19498-503}
}
Left-right asymmetry of the brain has been studied mostly through psychological examination and functional imaging in primates, leaving its molecular and synaptic aspects largely unaddressed. Here, we show that hippocampal CA1 pyramidal cell synapses differ in size, shape, and glutamate receptor expression depending on the laterality of presynaptic origin. CA1 synapses receiving neuronal input from the right CA3 pyramidal cells are larger and have more perforated PSD and a GluR1 expression… CONTINUE READING