Left posterior-dorsal area 44 couples with parietal areas to promote speech fluency, while right area 44 activity promotes the stopping of motor responses

  title={Left posterior-dorsal area 44 couples with parietal areas to promote speech fluency, while right area 44 activity promotes the stopping of motor responses},
  author={Nicole E. Neef and Christoph B{\"u}tfering and Alfred Anwander and Angela D. Friederici and Walter Paulus and Martin Sommer},
Shifted dynamic interactions between subcortical nuclei and inferior frontal gyri during response preparation in persistent developmental stuttering
Current findings in the traditional framework of how D1 and D2 receptor activity shapes focused movement selection are discussed, thereby suggesting a disproportional involvement of the direct and the indirect pathway in stuttering.
Brain regions that support accurate speech production after damage to Broca’s area
The brain activation patterns that underlie accurate speech production following stroke damage to the opercular part of Broca’s area are investigated and it is suggested that right Crus I and right pars opercularis play distinct roles in domain-general cognitive control.
Fluent speech: neural basis of sensorimotor plasticity in developmental stuttering
Structural and functional connectivity of the sensorimotor integration and inhibitory control network shape speech motor learning, and a heightened negative correlation between stuttering severity and fractional anisotropy in the superior longitudinal fasciculus is found.
Hemodynamics of speech production: An fNIRS investigation of children who stutter
Investigation of neural activation during natural, connected speech production in children who stutter demonstrates that in childhood stuttering, atypical functional organization for speech production is present and suggests promise for the use of fNIRS during naturalspeech production in future research with typical and atypicals child populations.
White matter tract strength correlates with therapy outcome in persistent developmental stuttering
Persistent stuttering is a prevalent neurodevelopmental speech disorder, which presents with involuntary speech blocks, sound and syllable repetitions, and sound prolongations. Affected individuals
Pitch and Duration Mismatch Negativity are Associated With Distinct Auditory Cortex and Inferior Frontal Cortex Volumes in the First-Episode Schizophrenia Spectrum
Investigation of relationships between gray matter and pMMN and dMMN in auditory and inferior frontal cortex in FESz revealed overlapping and distinct gray matter associations that may serve as biomarkers of underlying pathological deficits in both similar and slightly different cortical areas.
The frontal aslant tract (FAT) and its role in speech, language and executive function
This review examines the structural connectivity of a recently-identified fiber pathway, the frontal aslant tract (FAT), and suggests that the FAT plays a domain general role in the planning, timing, and coordination of sequential motor movements through the resolution of competition among potential motor plans.


A PET study of the neural systems of stuttering
Induced fluency decreased or eliminated the overactivity in most motor areas, and largely reversed the auditory-system underactivations and the deactivation of the speech production system, suggesting stuttering is a disorder affecting the multiple neural systems used for speaking.
The trajectory of gray matter development in Broca’s area is abnormal in people who stutter
In people who stutter, the pars opercularis did not demonstrate the typical maturational pattern of gradual gray matter thinning with age across the lifespan that was observed in control participants.
Structural and functional abnormalities of the motor system in developmental stuttering.
The data support the conclusion that stuttering is a disorder related primarily to disruption in the cortical and subcortical neural systems supporting the selection, initiation and execution of motor sequences necessary for fluent speech production.
Evidence of left inferior frontal-premotor structural and functional connectivity deficits in adults who stutter.
The authors' data provide strongest support for deficient left hemisphere inferior frontal to premotor connectivity as a neural correlate of stuttering.
Cortical plasticity associated with stuttering therapy.
Evidence for compensation for stuttering by the right frontal operculum
The Neurobiological Grounding of Persistent Stuttering: from Structure to Function
A meta-analysis of diffusion tensor imaging studies which have recently implicated disrupted white matter connectivity in stuttering revealed consistent deficits in the left dorsal stream and in the interhemispheric connections between the sensorimotor cortices.
A rostro-caudal gradient of structured sequence processing in the left inferior frontal gyrus
Two novel perspectives on the function of the left inferior frontal gyrus (LIFG) are presented, one from the viewpoint that functional segregation within the LIFG can be embedded in a general rostro-caudal abstraction gradient in the lateral PFC.
The frontal aslant tract underlies speech fluency in persistent developmental stuttering
The findings are the first to relate the FAT with fluent speech production in stuttering, adding to the current knowledge of the functional role that this tract plays in speech production and to the literature of the etiology of persistent developmental stuttering.
Opposite hemispheric lateralization effects during speaking and singing at motor cortex, insula and cerebellum
Findings corroborate the assumption that the left insula supports the coordination of speech articulation and suggest that the right insula might mediate temporo-spatial control of vocal tract musculature during overt singing.