Left hippocampal volume as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric study of nonpsychotic first-degree relatives.

@article{Seidman2002LeftHV,
  title={Left hippocampal volume as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric study of nonpsychotic first-degree relatives.},
  author={Larry J. Seidman and Stephen V Faraone and Jill M. Goldstein and William S. Kremen and Nicholas J. Horton and Nikos Makris and Rosemary Toomey and David K Kennedy and Verne S. Caviness and Ming T. Tsuang},
  journal={Archives of general psychiatry},
  year={2002},
  volume={59 9},
  pages={839-49}
}
BACKGROUND Clues to the causes of schizophrenia can be derived from studying first-degree relatives because they are genetically related to an ill family member. Abnormalities observed in nonpsychotic relatives are indicators of possible genetic vulnerability to illness, independent of psychosis. We tested 4 hypotheses: (1) that hippocampal volume is smaller in nonpsychotic relatives than in controls, particularly in the left hemisphere; (2) that hippocampi will be smaller in multiplex… CONTINUE READING

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