Left-handed Z-DNA: structure and function

  title={Left-handed Z-DNA: structure and function},
  author={Alan Herbert and A. Rich},
Z-DNA is a high energy conformer of B-DNA that forms in vivo during transcription as a result of torsional strain generated by a moving polymerase. An understanding of the biological role of Z-DNA has advanced with the discovery that the RNA editing enzyme double-stranded RNA adenosine deaminase type I (ADAR1) has motifs specific for the Z-DNA conformation. Editing by ADAR1 requires a double-stranded RNA substrate. In the cases known, the substrate is formed by folding an intron back onto the… CONTINUE READING
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Spectroscopic characterization of Za , a novel DNA binding domain from human ADAR 1 ,

  • I. Berger, R. ManoharanW.W., +5 authors A. Rich
  • Biochemistry
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Spectroscopic characterization of Za, a novel DNA binding domain from human

  • I. Berger, W.W.R. Manoharan, +5 authors A. Rich
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1 Excerpt

Structure / function analysis of the Z - DNA binding domain Za of ADAR 1 reveals similarity to ( a + b ) family of helix - turn - helix proteins

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  • EMBO J .
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Structure/function analysis of the Z-DNA binding domain Za of ADAR1 reveals similarity to (a+ b) family of helix- turn-helix proteins,EMBO

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  • 1998
12 Excerpts

A Z-DNA binding domain from the human editing enzyme dsRNA adenosine deaminase

  • A. Herbert, Y.-G. Kim, J. Alfken, K. Nishikura, A. Rich
  • Proc. Natl. Acad. Sci. USA
  • 1997
4 Excerpts

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