Left-handed Z-DNA: structure and function

@article{Herbert1999LefthandedZS,
  title={Left-handed Z-DNA: structure and function},
  author={Alan Herbert and A. Rich},
  journal={Genetica},
  year={1999},
  volume={106},
  pages={37-47}
}
Z-DNA is a high energy conformer of B-DNA that forms in vivo during transcription as a result of torsional strain generated by a moving polymerase. An understanding of the biological role of Z-DNA has advanced with the discovery that the RNA editing enzyme double-stranded RNA adenosine deaminase type I (ADAR1) has motifs specific for the Z-DNA conformation. Editing by ADAR1 requires a double-stranded RNA substrate. In the cases known, the substrate is formed by folding an intron back onto the… CONTINUE READING
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Structure / function analysis of the Z - DNA binding domain Za of ADAR 1 reveals similarity to ( a + b ) family of helix - turn - helix proteins

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