• Medicine
  • Published in
    The Cochrane database of…
    2003

Leflunomide for treating rheumatoid arthritis.

@article{Osiri2003LeflunomideFT,
  title={Leflunomide for treating rheumatoid arthritis.},
  author={Manathip Osiri and Beverley Shea and Vincent Robinson and ME Suarez-Almazor and Vibeke Strand and Peter Tugwell and George Anthony Wells},
  journal={The Cochrane database of systematic reviews},
  year={2003},
  volume={1},
  pages={
          CD002047
        }
}
BACKGROUND Rheumatoid arthritis (RA) is a chronic inflammatory joint disease. Leflunomide, as an inhibitor of pyrimidine synthesis, has a different mechanism of action than other existing disease modifying anti-rheumatic drugs (DMARD). OBJECTIVES To determine the efficacy and toxicity of leflunomide compared to placebo or other DMARDs in the treatment of RA. SEARCH STRATEGY We conducted a search in MEDLINE, EMBASE, Current Contents and the Cochrane Controlled Trial Register for trials up to… CONTINUE READING

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