Leflunomide for the Treatment of Rheumatoid Arthritis and Autoimmunity

@article{Sanders2002LeflunomideFT,
  title={Leflunomide for the Treatment of Rheumatoid Arthritis and Autoimmunity},
  author={S Sanders and Valee Harisdangkul},
  journal={The American Journal of the Medical Sciences},
  year={2002},
  volume={323},
  pages={190–193}
}
&NA; Leflunomide, a new oral immunomodulatory agent, is effective for the treatment of rheumatoid arthritis. Its mechanism of action in suppressing inflammation is based in its inhibition of dihydroorotate dehydrogenase, an enzyme responsible for de novo synthesis of pyrimidine containing ribonucleotides. It is the first disease‐modifying antirheumatic drug approved for treatment of rheumatoid arthritis with an indication for retardation of joint damage by radiography. Side effects are… 

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