Leflunomide-associated progressive multifocal leukoencephalopathy.

  title={Leflunomide-associated progressive multifocal leukoencephalopathy.},
  author={Megan R Rahmlow and Elizabeth A. Shuster and Jacob Dominik and Hugh Gordon Deen and Dennis W. Dickson and Allen J. Aksamit and Hector A Robles and William David Freeman},
  journal={Archives of neurology},
  volume={65 11},
A 68-YEAR-OLD MAN had a subacute progressive decline in speech and rightsided weakness after his rheumatoidarthritis regimenwas changedfromazathioprinetoleflunomide. His primary care physician diagnosedastroke.Threemonths later, in our neurology clinic, the patient soughttreatmentfortranscorticalmotor aphasia and mild right hemiparesis, and magnetic resonance imaging (MRI) was performed (Figure 1). Results showed bilateral subcortical, asymmetrical hyperintensities, without notable mass effect… CONTINUE READING
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