Leflunomide: is a new oral agent in treatment of acute pancreatitis?

@article{Kutluana2010LeflunomideIA,
  title={Leflunomide: is a new oral agent in treatment of acute pancreatitis?},
  author={Ufuk Kutluana and Nevin Oruç and Deniz Nart and Bunyamin Kaptanoğlu and Nadir Yonetci and Omer Ahmet Ozutemiz},
  journal={Pancreas},
  year={2010},
  volume={39 2},
  pages={237-42}
}
OBJECTIVES Nuclear factor-kappaB (NF-kappaB) is a potent mediator in several steps of acute pancreatitis. Leflunomide is a novel immunomodulating drug that is also a potent inhibitor of NF-kappaB activation. The aim of this study was to investigate the effects of leflunomide pretreatment in severe necrotizing pancreatitis in rats. METHODS Fifty rats were… CONTINUE READING