Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development.

@article{Kratochwil1996Lef1EI,
  title={Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development.},
  author={Karl Kratochwil and Maude Dull and Isabel Fari{\~n}as and Juan Galceran and Rudolf Grosschedl},
  journal={Genes & development},
  year={1996},
  volume={10 11},
  pages={1382-94}
}
Targeted inactivation of the murine gene encoding the transcription factor LEF-1 abrogates the formation of organs that depend on epithelial-mesenchymal tissue interactions. In this study we have recombined epithelial and mesenchymal tissues from normal and LEF-1-deficient embryos at different stages of development to define the LEF-1-dependent steps in tooth and whisker organogenesis. At the initiation of organ development, formation of the epithelial primordium of the whisker but not tooth is… CONTINUE READING
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