Lectin-resistant mutants of polarized epithelial cells.

  title={Lectin-resistant mutants of polarized epithelial cells.},
  author={H K Meiss and Ridgely Fisk Green and Enrique Rodriguez-Boulan},
  journal={Molecular and cellular biology},
  volume={2 10},
Two lectin-resistant mutants derived from Madin Darby canine kidney cells, with constitutive alterations in the asparagine-linked carbohydrate moieties, retained the characteristic structural and functional epithelial polarity of the parental cells. A ricin-resistant cell line was unable to incorporate galactose-sialic acid into glycoproteins and, from the pattern of cross-resistance to other lectins, appears to be different from previously described lines resistant to this lectin: the mutation… CONTINUE READING


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