Lectin pathway of complement activation and relation with clinical complications in critically ill children

@article{Ingels2014LectinPO,
  title={Lectin pathway of complement activation and relation with clinical complications in critically ill children},
  author={Catherine Ingels and Ilse Vanhorebeek and Rudi M Steffensen and Inge Derese and Lisbeth Jensen and Pieter Jozef Wouters and Greet Hermans and Steffen Thiel and Greet Van den Berghe},
  journal={Pediatric Research},
  year={2014},
  volume={75},
  pages={99-108}
}
Background:Critically ill children are susceptible to nosocomial infections, which contribute to adverse outcomes. Deficiencies in the innate immunity lectin pathway of complement activation are implicated in a child’s vulnerability to infections in conditions such as cancer, but the role during critical illness remains unclear. We hypothesized that low on-admission levels of the pathway proteins are, in part, genetically determined and associated with susceptibility to infectious complications… CONTINUE READING
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