Lectin-like oxidized low-density lipoprotein receptor-1 is required for the adipose tissue expression of proinflammatory cytokines in high-fat diet-induced obese mice.

@article{TakanabeMori2010LectinlikeOL,
  title={Lectin-like oxidized low-density lipoprotein receptor-1 is required for the adipose tissue expression of proinflammatory cytokines in high-fat diet-induced obese mice.},
  author={Rieko Takanabe-Mori and Koh Ono and Naoya Sowa and Hiromichi Wada and Tomohide Takaya and Takahiro Horie and Noriko Satoh-Asahara and Akira Shimatsu and Masatoshi Fujita and Tatsuya Sawamura and Koji Hasegawa},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={398 3},
  pages={576-80}
}
Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) is a receptor for oxidized LDL, and is strongly expressed in endothelial cells at an early stage of atherosclerosis. LOX-1 expression in adipocytes is induced by PPARgamma (ligands and appears to be involved in adipocyte cholesterol metabolism. However, the role of adipose tissue LOX-1 in high-fat diet-induced obesity is unknown. We found that mRNA levels of adipose tissue LOX-1 were markedly increased in obese mice fed a… CONTINUE READING