Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): a critical player in the development of atherosclerosis and related disorders.

@article{Mehta2006LectinlikeOL,
  title={Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): a critical player in the development of atherosclerosis and related disorders.},
  author={Jawahar Lal Mehta and Jiawei Chen and Paul L. Hermonat and Francesco Romeo and Giuseppe Novelli},
  journal={Cardiovascular research},
  year={2006},
  volume={69 1},
  pages={36-45}
}
LOX-1, a lectin-like 52-kD receptor for oxidized low-density lipoproteins (ox-LDL), is present primarily on endothelial cells. This receptor is upregulated by ox-LDL itself and by angiotensin II, endothelin, cytokines, and shear stress, all participants in atherosclerosis. This receptor is upregulated in the arteries of hypertensive, dyslipidemic, and diabetic animals. Upregulation of LOX-1 has been identified in atherosclerotic arteries of several animal species and humans, not only on the… CONTINUE READING
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