Lectin-induced apoptosis of tumour cells.

  title={Lectin-induced apoptosis of tumour cells.},
  author={Misson Kim and M. Veerabhadra Rao and David J Tweardy and Manu Prakash and Uri Galili and Elieser Gorelik},
  volume={3 5},
The mechanisms of cytotoxic activity of Griffonia simplicifolia 1-B4 (GS1B4) and wheat germ agglutinin (WGA) lectins against various murine tumour cell lines were studied. Tumour cells that lack lectin-binding carbohydrates were resistant to lysis by these lectins. However, YAC-1 cells that expressed GS1B4 lectin-binding sites showed low sensitivity to lysis. To further analyse the relative importance of cell surface carbohydrates in lectin cytotoxicity, BL6-8 melanoma cells, which do not… CONTINUE READING

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