Lectin-immobilized fluorescent nanospheres for targeting to colorectal cancer from a physicochemical perspective.

@article{Sakuma2011LectinimmobilizedFN,
  title={Lectin-immobilized fluorescent nanospheres for targeting to colorectal cancer from a physicochemical perspective.},
  author={Shinji Sakuma and Shinji Yamashita and Ken-ichiro Hiwatari and Robert M Hoffman and Wellington Pham},
  journal={Current drug discovery technologies},
  year={2011},
  volume={8 4},
  pages={367-78}
}
The goal of this research is to develop an imaging agent that enables real-time and accurate diagnosis of small-sized colorectal cancer. Since colorectal cancer initially develops in the mucous membrane of the large intestine, a nonabsorbable colonoscopic imaging agent capable of being administered intracolonically was designed. The imaging agent is peanut agglutinin (PNA)-immobilized polystyrene nanospheres with surface poly(N-vinylacetamide) (PNVA) chains encapsulating coumarin 6. PNA is a… CONTINUE READING