Lectin-epithelial interactions in the human colon.

  title={Lectin-epithelial interactions in the human colon.},
  author={Jonathan M. Rhodes and Barry J. Campbell and Lu-Gang Yu},
  journal={Biochemical Society transactions},
  volume={36 Pt 6},
Similar changes in glycosylation occur in the colonic epithelium in inflammatory conditions such as ulcerative colitis and Crohn's disease and also in colon cancer and precancerous adenomatous polyps. They include reduced length of O-glycans, reduced sulfation, increased sialylation and increased expression of oncofetal carbohydrate antigens, such as sialyl-Tn (sialylalpha2-6GalNAc), and the TF antigen (Thomsen-Friedenreich antigen) Galbeta1-3GalNAcalpha-Ser/Thr. The changes affect cell surface… 

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    Laboratory investigation; a journal of technical methods and pathology
  • 1983
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