Lectin anchored stabilized biodegradable nanoparticles for oral immunization 1. Development and in vitro evaluation.

@article{Gupta2006LectinAS,
  title={Lectin anchored stabilized biodegradable nanoparticles for oral immunization 1. Development and in vitro evaluation.},
  author={Prem Narayan Gupta and Sunil Mahor and Amit Rawat and Kapil Khatri and Amit Goyal and Suresh Prasad Vyas},
  journal={International journal of pharmaceutics},
  year={2006},
  volume={318 1-2},
  pages={163-73}
}
The investigation comprises development of a stable and targeted formulation of HBsAg for the oral immunization against Hepatitis B. PLGA nanoparticles bearing HBsAg was prepared by double emulsion method. The antigen was protected from organic/aqueous interface by using protein stabilizer, trehalose. The acidic environment generated within PLGA nanoparticles was neutralized by co-encapsulation of a basic additive, Mg(OH)(2) which provides an additional stabilization to the antigen especially… CONTINUE READING