Lecithinized superoxide dismutase retards wobbler mouse motoneuron disease

  title={Lecithinized superoxide dismutase retards wobbler mouse motoneuron disease},
  author={Katsuhisa Ikeda and Masao Kinoshita and Yasuo Iwasaki and Nobumi Tagaya and Toshiya Shiojima},
  journal={Neuromuscular Disorders},
Gene mutations of Cu/Zn superoxide dismutase (SOD) have been discovered in familial amyotrophic lateral sclerosis (ALS). Oxidative stress also plays a role in the pathogenesis of sporadic ALS. Whether antioxidant therapy is beneficial in this fatal disease is now crucial. We have shown that SOD treatment improves neuromuscular dysfunction and morphological changes in wobbler mouse motoneuron disease. Progressive spinal motor neuronopathy and axonopathy, predominantly in the cervical cord, occur… CONTINUE READING
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