Lecithinized superoxide dismutase induces vasodilation; evidence of direct contribution of superoxide anions to modulating vascular tone.

Abstract

The purpose of this study was to examine the role of superoxide anions in modulating the vascular tone. The effects of unmodified and lecithinized superoxide dismutase (SOD) on vascular tone were determined in aortic ring preparations of mice. In lecithinized SOD, 4 molecules of a phosphatidylcholine derivative were covalently bound to each dimer of… (More)

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@article{Nakamura1999LecithinizedSD, title={Lecithinized superoxide dismutase induces vasodilation; evidence of direct contribution of superoxide anions to modulating vascular tone.}, author={T. Nakamura and Rie Igarashi and Toshiaki Kurashina and Yoshinobu Saito and Jyunichi Hoshino and Hiroyuki Sumino and Hiroko Sakamoto and Ryozo Nagai}, journal={Life sciences}, year={1999}, volume={64 4}, pages={PL65-70} }