Lecithinized superoxide dismutase (PC-SOD) improved spinal cord injury-induced motor dysfunction through suppression of oxidative stress and enhancement of neurotrophic factor production.

@article{Takenaga2006LecithinizedSD,
  title={Lecithinized superoxide dismutase (PC-SOD) improved spinal cord injury-induced motor dysfunction through suppression of oxidative stress and enhancement of neurotrophic factor production.},
  author={Mitsuko Takenaga and Yuki Ohta and Yukie Tokura and Akemi Hamaguchi and Masaya Nakamura and Hideyuki Okano and Rie Igarashi},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2006},
  volume={110 2},
  pages={283-9}
}
PC-SOD (lecithinized superoxide dismutase) is a derivative of human Cu, Zn-SOD conjugated with 4 molecules of lecithin, yet having the enzyme activity of scavenging superoxide anion (O2-). Intravenous administration of PC-SOD promoted the recovery from spinal cord injury (SCI)-induced motor dysfunction in a dose-dependent manner in rat model, when evaluated by BBB (Basso Beattie Bresnahan) score. Even when given at 24 h after SCI, PC-SOD (1 mg/kg) significantly improved motor dysfunction… CONTINUE READING

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