Lecithinized brain-derived neurotrophic factor promotes the differentiation of embryonic stem cells in vitro and in vivo.

@article{Kitagawa2005LecithinizedBN,
  title={Lecithinized brain-derived neurotrophic factor promotes the differentiation of embryonic stem cells in vitro and in vivo.},
  author={Aki Kitagawa and Toshiaki Nakayama and Mitsuko Takenaga and Kayo Matsumoto and Yukie Tokura and Yuki Ohta and Manabu Ichinohe and Yoko Yamaguchi and Noboru Suzuki and Hideyuki Okano and Rie Igarashi},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={328 4},
  pages={1051-7}
}
The addition of lecithin molecules to brain-derived neurotrophic factor (BDNF) has been reported to markedly enhance its pharmacological effect in vivo. In the current study, we show that lecithinized BDNF (PC-BDNF) has a higher affinity than BDNF for neural precursor cells. Although BDNF only slightly increased the expression of the genes for Mash-1, p35, 68 kDa neurofilament, and TrkB receptor, PC-BDNF caused a significant increase in their expression. PC-BDNF also increased the level of… CONTINUE READING