Lecithin microemulsions for the topical administration of ketoprofen: percutaneous adsorption through human skin and in vivo human skin tolerability.

@article{Paolino2002LecithinMF,
  title={Lecithin microemulsions for the topical administration of ketoprofen: percutaneous adsorption through human skin and in vivo human skin tolerability.},
  author={Donatella Paolino and Cinzia Anna Ventura and Steven Paul Nistico and Giovanni Puglisi and Massimo Fresta},
  journal={International journal of pharmaceutics},
  year={2002},
  volume={244 1-2},
  pages={21-31}
}
The potential application of highly biocompatible o/w microemulsions as topical drug carrier systems for the percutaneous delivery of anti-inflammatory drugs, i.e. ketoprofen, was investigated. Microemulsions were made up of triglycerides as oil phase, a mixture of lecithin and n-butanol as a surfactant/co-surfactant system and an aqueous solution as the external phase. To evaluate the percutaneous enhancing effect of oleic acid, this compound was used as a component of some o/w microemulsions… CONTINUE READING

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