Lecithin: cholesterol acyltransferase (LCAT) deficiency and risk of vascular disease: 25 year follow-up.

@article{Ayyobi2004LecithinCA,
  title={Lecithin: cholesterol acyltransferase (LCAT) deficiency and risk of vascular disease: 25 year follow-up.},
  author={Amir Fardad Ayyobi and Sandra Helen McGladdery and Sammy Chan and Giovanni B John Mancini and Thomas L. Albright and Jiri J Frohlich},
  journal={Atherosclerosis},
  year={2004},
  volume={177 2},
  pages={
          361-6
        }
}
We have reassessed the clinical and biochemical status of a large Canadian kindred with LCAT deficiency 25 years after the initial investigations. There have been no vascular events or death in this family over the 25 years. Both the homozygous (N = 2) and heterozygous (N = 9) patients had highly abnormal lipid profiles with low HDL-C (extreme in the homozygotes); apo B levels were high in the heterozygotes. Lipoprotein and hepatic lipase activities were low in the homozygotes and several… CONTINUE READING
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