Lecithin/chitosan nanoparticles for transdermal delivery of melatonin.

@article{Hafner2011LecithinchitosanNF,
  title={Lecithin/chitosan nanoparticles for transdermal delivery of melatonin.},
  author={Anita Hafner and Jasmina Lovri{\'c} and Ivan Pepi{\'c} and Jelena Filipovi{\'c}-Gr{\vc}i{\'c}},
  journal={Journal of microencapsulation},
  year={2011},
  volume={28 8},
  pages={807-15}
}
In this study, the potential of lecithin/chitosan nanoparticles (NPs) as colloidal nanosystem for transdermal melatonin delivery was investigated. Mean diameter and zeta-potential of NPs differing in lecithin type (Lipoid S45 and S100) and chitosan content ranged between 113.7 and 331.5 nm and 4.6 and 31.2 mV, respectively. Melatonin loadings were up to 7.2%. The potential of lecithin/chitosan NPs to enhance transdermal melatonin delivery was investigated by determining the drug flux across… CONTINUE READING

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