Least squares estimation of molecular distance--noise abatement in phylogenetic reconstruction.

  title={Least squares estimation of molecular distance--noise abatement in phylogenetic reconstruction.},
  author={D. Goldstein and D. Pollock},
  journal={Theoretical population biology},
  volume={45 3},
Zuckerkandl and Pauling (1962, "Horizons in Biochemistry," pp. 189-225, Academic Press, New York) first noticed that the degree of sequence similarity between the proteins of different species could be used to estimate their phylogenetic relationship. Since then models have been developed to improve the accuracy of phylogenetic inferences based on amino acid or DNA sequences. Most of these models were designed to yield distance measures that are linear with time, on average. The reliability of… Expand

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