Learning smoothing models of copy number profiles using breakpoint annotations

@inproceedings{Hocking2012LearningSM,
  title={Learning smoothing models of copy number profiles using breakpoint annotations},
  author={Toby Hocking and Gudrun Schleiermacher and Isabelle Janoueix-Lerosey and Valentina Boeva and Julie Cappo and Olivier Delattre and Francis R. Bach and Jean-Philippe Vert},
  booktitle={BMC Bioinformatics},
  year={2012}
}
Many models have been proposed to detect copy number alterations in chromosomal copy number profiles, but it is usually not obvious to decide which is most effective for a given data set. Furthermore, most methods have a smoothing parameter that determines the number of breakpoints and must be chosen using various heuristics. We present three contributions for copy number profile smoothing model selection. First, we propose to select the model and degree of smoothness that maximizes agreement… CONTINUE READING
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