Learning of paw preference in mice is strain dependent, gradual and based on short-term memory of previous reaches

  title={Learning of paw preference in mice is strain dependent, gradual and based on short-term memory of previous reaches},
  author={A. Ribeiro and B. Eales and F. Biddle},
  journal={Animal Behaviour},
We studied the dynamics of paw preference learning in unbiased symmetrical test chambers where mice, Mus musculus, could freely choose which paw to use. When compared to nonlearner model mice, three strains exhibited different degrees of learning within and between two training sessions 1 week apart. While paw preference was probabilistic, positive autocorrelation between paw choices made by individual mice in a training session showed that bias in paw preference changed gradually with… Expand
Predictability and randomness of paw choices are critical elements in the behavioural plasticity of mouse paw preference
Lateralized paw usage of mice, Mus musculus, is a learned behaviour, based on a gradual reinforcement of randomly occurring weak asymmetries in paw choice early in training. The reinforcement reliesExpand
Short-term and long-term memory deficits in handedness learning in mice with absent corpus callosum and reduced hippocampal commissure
Positive autocorrelation between successive paw choices during each session and change in paw-preference bias between sessions indicate that 9XCA mice have weak, but not null, learning skills. Expand
Title: Short-term and Long-term Memory Deficits in Handedness Learning in Mice with absent Corpus Callosum and Reduced Hippocampal Commissure Short Title: Handedness Learning in Mice with absent Cc/hc
The corpus callosum (CC) and hippocampal commissure (HC) are major interhemispheric connections whose role in brain function and behaviors is fascinating and contentious. Paw preference of laboratoryExpand
Paw preference is associated with behavioural despair and spatial reference memory in male rats
Findings indicate paw preference as a vulnerability factor for behavioural despair and reveal a previously unknown association between left-paw preference and reference memory performance as assessed in the probe trial of the Morris water maze. Expand
Pawedness Trait Test (PaTRaT)—A New Paradigm to Evaluate Paw Preference and Dexterity in Rats
The pawdeness trait test (PaTRaT) is able to reliably classify rats’ pawedness direction and degree and was very high between two experienced raters and substantial when two additional inexperienced raters were included. Expand
Paw preferences in mice and rats: Meta-analysis
Meta-analysis is used to statistically integrated findings on paw preferences in rats and mice and indicates significant hemispheric asymmetries on the individual level, contrary to what has been reported in humans. Expand
Biological Limits of Hand Preference Learning Hiding Behind the Genes
This chapter describes hand-reaching behavior of mice and the discovery that it is a complex adaptive behavior in which future preference is genotypically dependent on past experience and defines the key elements that led to the collaborative development of a stochastic agent-based model. Expand
Does a nonprimate mammal, the northern tree shrew (Tupaia belangeri), exhibit paw preference in two forms of a grasping task?
Paw usage in tree shrews may result from a modification of a fixed motor pattern in which the preferred direction may be learned, a first step in the evolution of manual laterality, which eventually became controlled by vision in the primate lineage. Expand
Heritabilities of Directional Asymmetry in the Fore- and Hindlimbs of Rabbit Fetuses
The results showed a low but highly significant level of DA that is partially under genetic control for all traits, with forelimbs displaying higher levels of asymmetry. Expand
Lateralized scale-eating behaviour of cichlid is acquired by learning to use the naturally stronger side
Surprisingly, however, both maximum amplitude and angular velocity of body flexion during attack of naïve fish was dominant on one side, suggesting that scale-eating fish have a naturally stronger side for attacking prey fish, and they learn to use the dominant side through experience. Expand


Novelty affects paw preference performance in adult mice
The hemispheres are asymmetrically involved in the reaction to stressful situations. In this sense, it is possible to speculate that the asymmetrical activation of the hemispheres, as a result of theExpand
Genetic variation in paw preference (handedness) in the mouse.
There is evidence of significant deviation of the numbers of mice to the left and right of equal paw usage, independent of degree of lateralization, and this suggests that direction of left-right paw usage may be a separate genetic trait in the mouse model. Expand
Hand-preference training in the mouse reveals key elements of its learning and memory process and resolves the phenotypic complexity in the behaviour.
A detailed kinetic analysis of hand-preference training in the C57BL/6J strain revealed elements of the fundamental process of learning and long-term memory that underlies the behaviour by documenting consolidation of memory, blocking of this consolidation by an inhibitor of protein synthesis, retention of memory and speed of learning in response to training reaches. Expand
Spatial learning, discrimination learning, paw preference and neocortical ectopias in two autoimmune strains of mice
The finding that the left-pawed ectopic BXSB mice, who were the poorest learners in the non-spatial discrimination learning test, learned best in the spatial water escape test is in agreement with the Geschwind hypothesis that pathological events during brain development may, in some instances, produce superiority of function. Expand
Paw preference and intra-/infrapyramidal mossy fibers in the hippocampus of the mouse
The size and asymmetry of the IIP-MF projection are some of the many factors influencing the direction of paw preference and its strength, albeit moderately, and it is hypothesize that mice with larger IIp-MF projections use a given paw more consistently, being perhaps more resistant to interferences, and that left-right asymmetries of the IVM may bias and/or reinforce an initial choice of a paw. Expand
The degree of lateralization of paw usage (handedness) in the mouse is defined by three major phenotypes
In the expanded survey, some strains appear to exhibit a directional deviation from equal numbers of mice with left and right paw usage, suggesting direction of paw usage may not be a genetically neutral trait, but replicate assessments and genetic tests are needed to confirm this. Expand
Mouse genetic model for left-right hand usage: context, direction, norms of reaction, and memory.
A systematic series of tests of paw usage with naive mice and retests of the individuals in test chambers with the food tube biased to the left or to the right, contrasting the highly lateralized C57BL/6J and the very weakly lateralized (or ambilateral) CDS/Lay inbred strains and their (B6 x CDS) F1 generation resulted in an unexpected qualitative difference in paw usage. Expand
Dog paw preference shows lability and sex differences
It is concluded that behavioural lateralisation appears to be a labile category in dogs, and may be related to brain hemispheric effects in responding to novel stimuli. Expand
Dynamic Agent-Based Model of Hand-Preference Behavior Patterns in the Mouse
It is concluded that genetically evolved hand-preference behavior in mice is inherently probabilistic to provide robustness and allow constant adaptability to ever-changing environments. Expand
Lateralised behaviour in the domestic dog, Canis familiaris
  • D. Wells
  • Medicine, Psychology
  • Behavioural Processes
  • 2003
There are two distinct populations of paw preference in the domestic dog that cluster around the animals' sex, and it is recommended that further work be conducted to explore the influence of pre-training on dogs' paw preferences. Expand