Learning-induced reversal of the effect of noradrenalin on the postburst AHP.

@article{Brosh2006LearninginducedRO,
  title={Learning-induced reversal of the effect of noradrenalin on the postburst AHP.},
  author={Inbar Brosh and Kobi Rosenblum and Edi Barkai},
  journal={Journal of neurophysiology},
  year={2006},
  volume={96 4},
  pages={
          1728-33
        }
}
Pyramidal neurons in the piriform cortex from olfactory-discrimination-trained rats have reduced postburst afterhyperpolarization (AHP), for 3 days after learning, and are thus more excitable during this period. Such AHP reduction is caused by decreased conductance of one or more of the calcium-dependent potassium currents, I(AHP) and sI(AHP), that mediate the medium and slow AHPs. In this study, we examined which potassium current is reduced by learning and how the effect of noradrenalin (NE… 
View on PubMed
jn.physiology.org
31 Citations
Background Citations
17
Methods Citations
2
Results Citations
2

Figures from this paper

31 Citations

Citation Type

Citation Type

Serotonergic modulation of afterhyperpolarization in a neuron that contributes to learning in the leech.
TLDR
Modulation of S- cell AHP can contribute to 5-HT-mediated increases in excitability and that the S-cell afterpotential is due to the combined effects of AHP- and ADP-producing currents.
CAMKII Activation Is Not Required for Maintenance of Learning-Induced Enhancement of Neuronal Excitability
TLDR
The data show that although CaMKII modulates the amplitude of AHP of pyramidal neurons in the piriform cortex, its activation is not required for maintaining learning-induced enhancement of neuronal excitability.
A Novel Role for Extracellular Signal-Regulated Kinase in Maintaining Long-Term Memory-Relevant Excitability Changes
TLDR
The data show that ERK has a key role in maintaining long-lasting learning-induced enhancement of neuronal excitability, and the level of activated ERK in the membranal fraction was significantly higher in piriform cortex samples taken from trained rats.
Enhanced neuronal excitability in rat CA1 pyramidal neurons following trace eyeblink conditioning acquisition is not due to alterations in I M
Contribution of apamin-sensitive SK channels to the firing precision but not to the slow afterhyperpolarization and spike frequency adaptation in snail neurons
A Cellular Mechanism of Learning-Induced Enhancement of Synaptic Inhibition: PKC-Dependent Upregulation of KCC2 Activation
TLDR
It is concluded that learning-induced hyper-polarization of the fIPSP reversal potential is mediated by PKC-dependent increase of KCC2 phosphorylation, which is expressed by wide spread enhancement in excitatory and inhibitory synaptic transmission onto piriform cortex pyramidal neurons.
A Cellular Mechanism Underlying Enhanced Capability for Complex Olfactory Discrimination Learning
TLDR
It is shown that brief activation of the GluK2 subtype glutamate receptor results in long-lasting enhancement of neuronal excitability in neurons from controls, but not from trained rats, and signaling via kainate receptors has a central functional role in higher cognitive abilities.
Learning-induced modulation of the GABAB-mediated inhibitory synaptic transmission: mechanisms and functional significance.
TLDR
It is suggested that complex OD learning is accompanied by enhancement of the GABAB-mediated inhibition that enables the cortical network to store memories, while preventing uncontrolled activity.
Profound alterations in the intrinsic excitability of cerebellar Purkinje neurons following neurotoxin 3-acetylpyridine (3-AP)-induced ataxia in rat: new insights into the role of small conductance K+ channels.
TLDR
Ataxia may arise from alterations in the functional contribution of SK channels, to the intrinsic properties of Purkinje cells.
A non-synaptic mechanism of complex learning: Modulation of intrinsic neuronal excitability
...
1
2
3
4
...

References

SHOWING 1-10 OF 46 REFERENCES
Long-Lasting Cholinergic Modulation Underlies Rule Learning in Rats
TLDR
It is suggested that intense ACh activity during rule learning enhances neuronal excitability in the piriform cortex by reducing IAHP and that the effect outlasts the stage of rule learning, so that A Ch activity is not crucial for further odor learning.
SHORT COMMUNICATION Learning‐induced reduction in post‐burst after‐hyperpolarization (AHP) is mediated by activation of PKC
TLDR
It is suggested that while the post‐burst AHP in piriform cortex pyramidal neurons is modulated by both PKC and PKA, a PKC‐dependent process maintains the learning‐related reduction of the A HP in these cells.
An apamin-sensitive Ca2+-activated K+ current in hippocampal pyramidal neurons.
TLDR
It is reported that CA1 pyramidal neurons express an AHP current that is suppressed by apamin and is involved in the control of repetitive firing and may explain the effects of this toxin on hippocampal synaptic plasticity and learning.
An apamin-sensitive Ca 21 -activated K 1 current in hippocampal pyramidal neurons
TLDR
It is reported that CA1 pyramidal neurons express an AHP current that is suppressed by apamin and is involved in the control of repetitive firing, and this current presents distinct kinetic and pharmacological features, and it is modulated differently than the apamin-insensitive slow AHPCurrent.
Age-Related Enhancement of the Slow Outward Calcium-Activated Potassium Current in Hippocampal CA1 Pyramidal Neurons In Vitro
TLDR
The data, in conjunction with previous studies showing a correlation between the AHP and learning, suggest that the enhancement of the sIAHP in aging is a mechanism that contributes to age-related learning deficits.
Watermaze learning enhances excitability of CA1 pyramidal neurons.
TLDR
The AHP and one or more of its associated currents (IAHP and/or sIAHP) are reduced in dorsal hippocampal CA1 pyramidal neurons from rats that learned the watermaze task as compared with neurons from control rats.
Voltage clamp analysis of cholinergic action in the hippocampus
TLDR
The slow EPSP appears to be generated by the blockade of a nonvoltage- dependent, resting potassium current, and it is proposed that the muscarinic blockade of IAHP is primarily involved in enhancing action potential discharge to depolarizing stimuli, while theslow EPSP acts directly to cause action potential discharged.
Action of serotonin on the hyperpolarization‐activated cation current (Ih) in rat CA1 hippocampal neurons
TLDR
5‐HT modulates Ih by shifting its activation curve to more positive voltages and by increasing its maximal conductance, and that this action is likely to contribute to the 5‐HT modulation of excitability of CA1 cells.
Transient changes in excitability of rabbit CA3 neurons with a time course appropriate to support memory consolidation.
TLDR
The restriction of the observed changes to two interrelated measures of excitability concurs with earlier reports that learning-specific changes in the mammalian hippocampus are linked to changes in a limited number of membrane conductances.
Trace Eyeblink Conditioning Increases CA1 Excitability in a Transient and Learning-Specific Manner
TLDR
Time-dependent, learning-related changes in hippocampal excitability were evaluated by recording from rabbit CA1 pyramidal neurons in slices prepared at various times after acquisition of trace eyeblink conditioning, suggesting a critical window during which learning-specific alterations in postsynaptic excitability of hippocampal neurons are important for consolidation of the learned association elsewhere in the brain.
...
1
2
3
4
5
...